Hair Follicle Regeneration Therapy Using Hair Follicle Stem Cells.

There have been recent developments in hair follicle regeneration therapy and regenerative medicine using hair follicle stem cells.

In the research on hair follicle regeneration therapy, it has been reported that the injection of connective tissue hair root sheath cells, extracted from the hair follicles of the back of the head, into the balding areas of patients with male pattern baldness, leads to improvements in the amount and thickness of hair. This is being regarded as a promising treatment for refractory alopecia.

On the other hand, research on regenerative medicine using hair follicle stem cells has shown promising results in the treatment of nerve regeneration and spinal cord injuries in mice. Specifically, by transplanting hair follicle stem cells into specific nerve sites, peripheral nerves and central nerves are regenerating, and improvements in motor function are also being observed.

Additionally, research is underway to create cardiac muscle cells from hair follicle stem cells. By transforming rat hair follicle stem cells into cardiac muscle, there is an indication that the number of heart muscle cells increases, and the regeneration of the damaged part of the heart is being promoted. This method has a higher safety profile than other stem cells, such as iPS cells, and clinical applications are expected in the regeneration therapy of peripheral nerves, spinal cords, and hearts.

Overall, hair follicle regeneration therapy and regenerative medicine using hair follicle stem cells are fields opening up new prospects in treatments such as hair loss, nerve regeneration, and heart regeneration, and further research is increasingly expected.

Dr. Munenori Matsuzawa, Chief Medical Officer, Aoyama Medical Clinic.

References：
1) Yamazaki A, Yashiro M, Mii S, et al: Isoproterenol di- rects hair follicle-associated pluripotent (HAP) stem cells to differentiate in vitro to cardiac muscle cells which can be induced to form beating heart-muscle tis- sue sheets, Cell Cycle. 2016:15:760-765.
2) Takaoka N, Yamane M, Obara K, et al: Hair-follicle- associated pluripotent (HAP) stem cells differentiate

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松澤 宗範青山メディカルクリニック 院長

近畿大学医学部卒業。慶應義塾大学病院形成外科入局し、佐野厚生総合病院形成外科へ。その後、横浜市立市民病院形成外科として務める。埼玉医科総合医療センター形成外科・美容外科を経て、銀座美容外科クリニック新宿院院長として従事する。その後、青山メディカルクリニック開設し、今に至る。

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